While the volume may be similar to a physical space in the body it is not necessary to assume that the apparent volume corresponds to an anatomicalphysiological volume. Drugs that have a volume of distribution 7 4 l or less are thought to be confined to the plasma, or liquid part of the blood. The volume of distribution vd, also known as apparent volume of distribution, is a pharmacological term used to quantify the distribution of a medication between plasma and the rest of the body after oral or parenteral dosing. The volume distribution is the theoretical volume into which for example a drug is distributed into the body. The volume of distribution v d, also known as apparent volume of distribution, is used to quantify the distribution of a drug between plasma and the rest of the body after oral or parenteral dosing. The volume of distribution is a hypothetical amount, meaning that it is not a real volume, but instead is a concept of volume.
For a similar log p, a basic molecule will tend to exhibit higher volume of distribution than a neutral molecule. Volumes of distribution should be determined early in drug development programmes and those having a large volume of distribution may be selected to obtain a long terminal halflife even for drugs. Volume of distribution pharmacology lect 5 youtube. The volume of distribution vd, also known as apparent volume of distribution, is a pharmacologic term used to quantify the distribution of a drug throughout the body after oral or intravenous dosing. If the volume is between 7 4 and 15 7 l, the drug is thought to be distributed throughout the blood plasma and red blood cells. The definition of apparent volume of distribution v links drug concentration to the amount of drug in the body. The apparent volume is the volume into which the drug is known to distribute in the. Fluid compartments of 70kg subject in liters and as percent of body weight. Significance of the apparent volume of distribution answers. Volume of distribution an overview sciencedirect topics. Learn vocabulary, terms, and more with flashcards, games, and other study tools. In pharmacology, the volume of distribution v d, also known as apparent volume of distribution, literally, volume of dilution is the theoretical volume that would be necessary to contain the total amount of an administered drug at the same concentration that it is observed in the blood plasma. It is a major determinant of halflife and dosing frequency of a drug. This lesson will discuss the definition and significance of volume of.
It is defined as the volume in which the amount of drug would need to be uniformly distributed to produce the observed blood concentration. It is defined as the volume in which the amount of drug would need to be uniformly distributed to. Volume of distribution is one of the most important pharmacokinetic properties of a drug candidate. Introduction volume of distribution v d, is defined as the volume in which the amount of drug would be uniformly distributed to produce the observed blood concentration.
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